Chiplet architectures are becoming foundational to the continued economic and power-efficient scaling of AI hardware and edge computing. As Moore’s Law slows, the convergence of system integration and advanced packaging has emerged as a critical enabler at the intersection of technology and architecture. This keynote will explore how heterogeneous integration—spanning 2.5D and 3D hybrid bonded architectures—is driving AMD’s industry-leading roadmap to optimize power, performance, area, and cost (PPAC). Beyond packaging, the talk will highlight the broader system-level innovations required to integrate diverse chiplets into cohesive, high-performance modules. Topics will include chiplets for AI, system integration challenges, interconnect strategies, and solutions for large-scale chiplet-based systems.